Cancer metastatic to lymph node axilla. FACTORI PROGNOSTICI ÎN CANCERUL MAMAR
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- Lung Cancer or Metastasis to Lung?
Many environmental factors are recognized as carcinogenic in humans for this form of neoplasia and some of them are related to occupation. In order to illustrate these effects, we have selected several relevant cases with smoking and occupational exposure to carcinogens and their histopathological findings.
We reviewed the most important research published in the field of environmental-genomic interaction in relation with the oncogenesis of BC. Three main directions have been identified and described in the article: the environmental factors involved in BC pathogenesis and evolution, the molecular mechanisms involved in cell mitosis control and xenobiotic metabolism related to the qualitative and quantitative exposure and, finally, the possible biomarkers of the tumor evolution.
From the genomic and proteomic research, new biomarkers emerged that are in the validation process. Immunohistochemical methods open also new perspectives to the cancer metastatic to lymph node axilla algorithms and could serve as prognosis biomarkers.
In the 6th and 7th editions of the American Joint Committee on Cancer AJCC Cancer Staging Manual are evaluated the nodal metastases based on size and taking into account the number of metastatic cells.
According to these Manuals, a positive node is equated to metastasis whose size reaches at least 0. The clinical significance and the therapeutic optimum of the presence of tratament de coacăz pentru paraziți minimal nodal involvement after axillary sentinel lymph nodes SLNs biopsy remain controversial. The need for further axillary treatment ALN dissection or axillary radiation in clinical N0 patients with early-stage breast carcinoma and SLNs metastases remains unclear.
In all likelihood, the delivery of the regular adjuvant treatment in association with systemic treatment and radiation therapy results in survival rates similar to axillary treatment completion.
This review also presents several assessment methods related to the SLNs at the surgical stage, such as cytological, histological, immunohistochemical and molecular diagnostic techniques, evaluating the advantages and disadvantages of each of them. More studies including larger groups of breast patients are needed to confirm which of them is the most reliable method for the evaluation of the SLNs.
The purpose of this review is to briefly present the etiology of ALI and morphological findings in correlation with specific causes.
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Etiology can be classified into two main groups: prenatal in utero compression, thrombosis and embolism and postnatal iatrogenic, thromboembolism and vascular malformations. Ultrasound represents a non-invasive, inexpensive and widely available imaging technique, which provides sufficient information to evaluate the situation and establish proper therapeutic strategies. Morphological tests do not represent the standard diagnostic procedure in ALI, but they can provide useful information.
The findings depend on the etiology: intraluminal thrombi, vascular changes, placental pathological modifications. Every morphological result must be correlated with the clinical picture and imagistic findings. In conclusion, ALI in neonates is a rare hpv treatment uptodate, usually associated with catheter use in intensive care unit setting, with multiple risk factors and conditions that increase the risk of occurrence.
A review of the influence the anxiety exerts on human life Dan Nechita, Florina Nechita, Raluca Motorga Our intention has been to review the literature addressing the anxiety phenomenon from as many points of view as possible.
Evans is a year-old woman who is sitting in your office awaiting your assessment of her recent diagnosis of melanoma. She had initially presented to her primary care physician 6 weeks earlier with an irregular lesion on her right arm.
By searching in PubMed and Web of Science and by using multiple filters, we have included, of the over results, 93 studies with the aim of covering more aspects of life anxiety exerts its influence upon.
We have discussed the connection between anxiety and physiological and psychological functioning, or its connection with the areas of family, religion, social life and behavior, as hpv warts reddit as the cultural side, childhood, pregnancy and many others.
The control group consisted of women. All subjects were genotyped by means of allelic discrimination TaqMan polymerase chain reaction assay with specific probes. AA: odds ratio OR 1.
AA: OR 1. These results prove that G cancer metastatic to lymph node axilla carriers have an increased risk of RPL about 1. Although our results bear limited statistical significance, the study nonetheless represents a step forward in the evaluation of recurrent abortion, which has not yet been explored sufficiently.
Therefore, further studies, which include a larger sample size, are required in order to clarify the role of KDR polymorphism in RPL.
The role of glomerular morphometric features in pediatric podocytopathies - a single center study Diana Derewicz, Valentin Tiberiu Moldovan, Leila Ali, Roxana Taras, Cosmin Florescu, Mihaela Balgradean, Maria Sajin Podocytopathies represent a well-studied subgroup of glomerulopathies, being characterized by proteinuria due to damage or dysfunction of podocytes.
Glomerular size in podocytopathies has been studied in different population, but only a few studies take in consideration the pediatric population.
There are different methods squamous papilloma from hpv assess the glomerular size, but most of the studies report the maximal profile area as being the most accurate one.
The aim of this study is to determine the range values of glomeruli in pediatric population with glomerulopathies and to establish a correlation between the measured size and several laboratory features. The control group included children that require renal biopsy for renal impairments other than high-range proteinuria most of them recurrent microscopic asymptomatic hematuriawhile the affected group had nephrotic-range proteinuria.
Thirty patients were selected to be part of the control group and 30 patients in the affected group. In control group, the mean value diameter was In the affected group, we obtained the following results: the mean value diameter was Using the linear regression, we concluded that all the cases with increased-size glomeruli had more urinary protein loss compared with the ones that had small-size glomeruli and low-range proteinuria.
A novel combination of double primary malignancies: penile carcinoma and glioblastoma. The aim of our paper is to present two patients diagnosed and treated for a cerebral GB developed after cancer metastatic to lymph node axilla prior pSCC and to discuss the possible mechanism of their association.
Nicolae Oblu Emergency Clinical Hospital, Iasi, Romania, between April and Aprilwere retrospectively searched for those having a cancer metastatic to lymph node axilla histological proven cancer. The review found only two patients 0. Results: Both patients were year-old on their admission in the Department of Neurosurgery. Their prior penile tumors were both located at the penis glans. In both cases, the histopathological exam revealed a penile keratinized squamous cell carcinoma stage T1aN0M0 at the moment of their first urological diagnosis.
At the time of the neurosurgical evaluation, brain radiological investigations demonstrated right frontal cystic neoformation in the first case, and a right frontal-parietal solid, expansive lesion for the second patient. The patients underwent subtotal surgical excision of their brain masses. Conclusions: This is the first clinical report of a new association between pSCC and subsequent development of GB in a series of two patients. Both our patients developed a prior pSCC without any lymph node and distant metastasis at their first diagnosis and this situation reinforces the idea that this type of cancer has a good prognosis and that cancer metastatic to lymph node axilla patient can develop a second cancer during his post-penectomy life, probably due to a tratarea mărgelelor rotunde predisposition, post-therapeutic effects, life style factors smoke effectssporadic association, or due to the common embryological origin of the nervous and skin tissues.
Intestinal fatty acid-binding protein, as a marker of anastomotic leakage after colonic resection in rats Gabriel Alexandru Popescu, Ioan Jung, Bogdan Andrei Cordos, Leonard Azamfirei, Adina Hutanu, Simona Gurzu Aim: The aim of this experimental study was to determine if the type of termino-terminal anastomosis of the colon affect the process of healing of the intestinal mucosa and if the severity of the anastomotic leakage AL can be predicted based on the circulating level of intestinal fatty acid-binding protein I-FABP.
To assess the intestinal barrier function, circulating level of I-FABP was measured pre- and post-operatively. I-FABP tissue expression was immunohistochemically assessed in the anastomotic and perianastomotic colonic mucosa. The rats were sacrificed at three, five, and seven days after surgery. Results: In both groups, the post-operative serum level of I-FABP increased times at days and seven times in the seventh post-operative day. A increased value in first five days might indicate a risk of AL.
After seven days, a seven times increased value is an indicator of a proper healing process but an increasing amount higher that 30 times might predict risk for AL, fistula, peritonitis and septic shock. The risk of AL does not depend on the anastomotic method, although the level of ischemia is higher in anastomoses that involve vascular damage.
Hand enchondroma - complete vindecă viermii and rehabilitation Magdalena Rodica Traistaru, Diana Kamal, Raluca Niculina Ciurea, Paraschiva Postolache, Dragos Ovidiu Cancer metastatic to lymph node axilla, Otilia Constantina Rogoveanu, Kamal Constantin Kamal Enchondroma, the most frequently reported primary tumor in the long bones of the hand, is a common benign cartilaginous tumor, defined more exactly as a benign mature hyaline cartilaginous tumor that is located into the medullar space of the tubular bones.
Between andwe performed an observational study on six patients two males and four femalesaged 16 to 49 years old mean The tumor was more frequently located in their proximal phalanges four patientswhile two patients had cancer metastatic to lymph node axilla phalange tumors.
The most common digit involved cancer metastatic to lymph node axilla the little finger five patientsfollowed by the ring finger one patient. The symptoms, which prompted surgical interventions, were: enlargement without fracture two patientspain or limitation of mobility four patientspain without pathological fracture six patients. Studied patients were completely assessed before the treatment program surgical intervention and rehabilitation program.
Histological assessment and differential diagnosis are essential for the post-surgical treatment and rehabilitation program. Identifying elements that may suggest the malignant nature of a lesion and obtaining biopsy specimens sufficient for a reliable pathological analysis remain difficult challenges.
Narrow-band imaging NBI technology appears to provide a more accurate observation of the upper tract urothelium. All suspicious areas of the pyelocaliceal urothelium were biopsied using the grasping forceps, separately for WL and NBI findings. Overall, 13 pTa and two CIS lesions were solely observed in NBI, which was on the other hand characterized by a significantly increased proportion of unnecessary biopsies NBI versus WL rate of false-positive results - Conclusions: As additional tool for the standard WL evaluation of the pyelocaliceal system urothelium, NBI-guided biopsies were emphasized cancer metastatic to lymph node axilla providing a significant diagnostic improvement during digital FURS.
We performed a prospective study that included patients with IBD Crohn s disease - CD, ulcerative colitis - UC or undifferentiated colitis - CN diagnosed between and in the Northeastern region of Romania. The patients were extracted from the national database IBD Prospect. Only 10 patients were diagnosed with CN. Musculoskeletal manifestations were the most common EIM. Patients with CD had a 3. Evaluation of antioxidant capacity and clinical assessment of patients with chronic periodontitis treated with non-surgical periodontal therapy and adjunctive systemic antibiotherapy Simina Boia, Stefan-Ioan Stratul, Marius Boariu, Sorin Ursoniu, Smaranda Laura Gotia, Eugen Radu Boia, Claudia Borza This study aims to evaluate the oxidative stress changes in patients with chronic periodontitis CP undergoing non-surgical periodontal therapy alone, compared with non-surgical periodontal therapy with adjunctive systemic antibiotic therapy.
Venous blood and unstimulated saliva samples were collected. Non-surgical periodontal therapy was performed simultaneously with antibiotics administration.
Cancer metastatic to lymph nodes
Oxidative stress balance was evaluated by measuring derivatives of reactive oxygen metabolites d-ROMs and the biological antioxidant potential BAP in plasma. After the microscopic evaluation of the pathological aspect of the epithelial cells ECstheir number, viability and the presence of C-reactive protein CRP were reevaluated from saliva at seven days, while reduced glutathione GSH level, d-ROMs and BAP at three months.
Wilcoxon and Kruskal-Wallis rank-tests were used for statistics. In test group patients, oxidative stress status changed from a very high level to a medium one, suggesting that adjunctive use of antibiotics could have contributed to the reduction of reactive oxygen metabolites, along with significant clinical improvements.
Virchow's Node (Left Supraclavicular Lymph Node) helminth immune modulation
In this study, we examined the immunohistochemical expression of p53 and cyclooxygenase-2 COX-2 in 51 BCCs, nodular and infiltrative subtypes, with various Clark levels. The immunoexpression of p53 was identified in The scores of p53 reactions revealed significant differences depending on Clark level and borderline significance with tumor type, the high positive scores being associated to infiltrative tumors and high Clark level.
No differences were revealed between COX-2 scores with both Clark level and tumor type.
This fact is due to the frequency of this disease which continues to persist at high values, and its evolution is severe especially when it is diagnosed in a late stage of the disease9. Over time, however, new ways have emerged to reduce breast cancer mortality. Thus, breast screening that allows the discovery of the disease in less advanced stages or prior to clinical manifestations, where the number of healings increases considerably.
The analysis of the percentage values of p53 and COX-2 indicated a positive linear correlation. The positivity of p53 and COX-2 in a large proportion of BCCs, regardless of histological type and of depth of invasion, supports the two markers involvement in tumor progression. The process of liver fibrosis in chronic hepatitis C - histological and cancer metastatic to lymph node axilla study Nicoleta Laura Popescu, Octavian Ion Predescu, Oana Badea, Ionica Pirici, Carmen Pantis, Cristina Jana Busuioc, Bogdan-Virgil Cotoi, Laurentiu Mogoanta Liver fibrosis is one of the most serious histopathological HP lesions that, together with the inflammatory process and the hepatocyte lesions, determine the change of helminthiasis neem liver architecture, having as a clinical result the onset of liver failure phenomena.
Hepatitis C virus represents one of the most frequent conditions leading to the onset of liver fibrosis and favors the progression of the disease towards hepatocellular carcinoma.
We evaluated the HP and immunohistochemical IHC aspects on fragments of liver biopsies taken from patients diagnosed with chronic hepatitis C and altered capacity of work. In our study, we observed a growth of the portal Kiernan spaces by the presence of a chronic inflammatory infiltrate, the presence of collagen fibers and conjunctive matrix.
Cancer metastatic to lymph nodes What does it mean if breast cancer spreads to the lymph nodes? Over time, however, new ways have emerged to reduce breast cancer mortality.
The density and dimensions of collagen fibers were correlated with the severity of the liver disease, in the severe forms being highlighted porto-portal and porto-central fibrous bridges. The IHC examinations highlighted the change of the phenotype of perisinusoidal dendritic cells, the growth of the myofibroblast cells in the portal spaces, the growth of the macrophage number in the inflammatory infiltrate and of the Kupffer cells in the liver parenchyma.
UPA effects on endometrium - what is the significance? In Romania, despite the UPA availability, physicians remained reserved on the lack of experience and concerns about the safety of the drug on endometrium. Patients, Materials and Methods: We performed an observational study on premenopausal women with symptomatic uterine fibroids.
The patients received UPA in doses of 5 mg for weeks. The fibroids dimensions and endometrium thickness were recorded at before and after the treatment. Results: A number of 57 women were introduced in our study and we had a dropout of one patient. The fibroid dimensions and endometrial thickness decreased after UPA. EPAEC were more frequent in patients with larger fibroids.
Conclusions: UPA treatment decreased fibroids dimension and improved patients symptoms in our study.
Traducere "ganglionilor limfatici santinelă" în engleză
UPA administration for three months is a safe method without endometrial atypia but longer protocols require extended studies about the proliferative potential of the endometrium. PDF It is represented by the ectopic presence of the endometrial glandular epithelium in papilloma virus uomo antibiotico tissues and organs. This ectopically located tissue can display premalignant or even malignant changes under the influence of certain factors that affect cell structure, function and proliferation.
Our study includes a total of 28 patients, with endometriosis of different localizations: ovarian or pelvic endometriosis, adenomyosis or endometriosis of the abdominal wall. We performed a clinical and statistical analysis upon the collected clinical and laboratory data, together with the results obtained by using classical histological and immunohistochemical IHC profiling.
The median age was 47 years range years. All data were obtained retrospectively. Most of the patients The most common clinical manifestation was non-specific abdominal pain The median cyst size was 7 cm, with cancer metastatic to lymph node axilla range between 2 cm and 15 cm. There were 35 procedures in 31 patients in four patients the resection was preceded by a drainage procedure.
From the 28 resections, most of them Most of the resections In all cases, the final diagnosis was based on histological examination that revealed columnar epithelium and ovarian-type stroma. Postoperative complications occurred in 10 Postoperative mortality was 3.
Conclusions: MCAs represent a rare pancreatic pathology with challenging diagnostic and therapeutic implications. Oncological surgical resections are recommended. Histopathological examination establishes the final diagnosis. The most common postoperative complication is pancreatic fistula. Corresponding author: Emil Matei, MD; e-mail: emmatei gmail. Visceral adipose tissue secretes over 50 inflammatory cytokines that can act centrally to regulate different physiological processes of the body but also remotely involved in communicating messages from the adipose tissue to other target tissues.
The purpose of this study is to demonstrate the effect of in vitro adipose mesenchymal stem cells MSCs on endometrial tumor cells. Materials and Methods: Adipose-derived stem cells ASCs were isolated from normal subcutaneous SC and omentum adipose tissue from one woman without any other pathologies associated during a Fallopian tube ligature intervention.
From one patient with EC was also harvested both SC and omentum adipose tissue. Ishikawa cells were cultured in ASCs conditioned medium. Study outcomes included detection of adipokines in cell culture supernatants and cell lysates by the enzyme-linked immunosorbent assay Cancer metastatic to lymph node axilla. Results: Our results indicate that cells from the EC patient s fat tissues migrated during the first days of cultivation and had a high proliferation rate.